Highly Efficient Synthesis of 1H-Indazole-3-carboxylic Acid Derivatives via Diazotization Reaction

1-Methyl-1H-indazole-3-carboxylic acid

The asymmetric unit of the title compound, C(9)H(8)N(2)O(2), contains two mol-ecules. In the crystal structure, both mol-ecules form inversion dimers via pairs of O-H⋯O hydrogen bonds, and a C-H⋯O inter-ation is also seen.

Synthesis and biological evaluation of some new Aryl acid N'-(1H- indazole-3-carbonyl)-hydrazide derivatives

Recent drug discovery efforts are highly focused towards design and synthesis of small molecules of protein kinase C-β/AKt inhibitiors. 2 A wide ranges of heterocyclic ring systems has been studied for the development of novel chemical entities as lead molecules in the drug discovery paradigm. Indazole derivatives are one of the privileged structural fragments in medicinal chemistry having broa...

Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction

Trichloroacetic Acid (TCA) was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in MeOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and an easy wo...

Synthesis of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives of potential anti-inflammatory activity.

A series of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives 4-10 were synthesized by rearrangement of 4-(3-pyridyl)-hydrazono-2-phenyl-2-oxazolin-5-one 3 in the presence of different nucleophiles to afford derivatives 4, 7, and 8, while hydroxamic acid derivative 6 was prepared from reaction of methyl ester 4 with hydroxylamine hydrochloride. Semicarbazide 9 and thiosemic...

trichloroacetic acid as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component reaction